CRX (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human CRX full-length ORF ( AAH16664, 1 a.a. - 299 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MMAYMNPGPHYSVNALALSGPSVDLMHQAVPYPSAPRKQRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKQQQQPPGGQAKARPAKRKAGTSPRPSTDVCPDPLGISDSYSPPLPGPSGSPTTAVATVSIWSPASESPLPEAQRAGLVASGPSLTSAPYAMTYAPASAFCSSPSAYGSPSSYFSGLDPYLSPMVPQLGGPALSPLSGPSVGPSLAQSPTSLSGQSYGAYSPVDSLEFKDPTGTWKFTYNPMDPLDYKDQSAWKFQIL
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
58.63
Interspecies Antigen Sequence
Mouse (97); Rat (97)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — CRX
Entrez GeneID
1406GeneBank Accession#
BC016664Protein Accession#
AAH16664Gene Name
CRX
Gene Alias
CORD2, CRD, LCA7, OTX3
Gene Description
cone-rod homeobox
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq
Other Designations
cone-rod homeobox protein|orthodenticle homeobox 3
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Interactome
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Disease
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Publication Reference
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Plasma Antiretinal Autoantibody Profiling and Diagnostic Efficacy in Patients With Autoimmune Retinopathy.
Seok Hyun Bae, Hye Kyoung Hong, Jong Young Lee, Min Seok Kim, Christopher Seungkyu Lee, Min Sagong, Sook Young Kim, Baek-Lok Oh, Young Hee Yoon, Jae Pil Shin, Young Joon Jo, Kwangsic Joo, Sang Jun Park, Kyu Hyung Park, Se Joon Woo.
American Journal of Ophthalmology 2022 Jul; 245:145.
Application:WB, Human, Human plasma.
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CRX Is a Diagnostic Marker of Retinal and Pineal Lineage Tumors.
Santagata S, Maire CL, Idbaih A, Geffers L, Correll M, Holton K, Quackenbush J, Ligon KL.
PLoS One 2009 Nov; 4(11):e7932.
Application:Dot, IHC, Human, H120 Crx antibody, human retina and retinoblastoma.
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Plasma Antiretinal Autoantibody Profiling and Diagnostic Efficacy in Patients With Autoimmune Retinopathy.
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