CRX monoclonal antibody (M01), clone F6-C2
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of CRX expression in transfected 293T cell line by CRX monoclonal antibody (M01), clone F6-C2.
Lane 1: CRX transfected lysate(32.261 KDa).
Lane 2: Non-transfected lysate.
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged CRX is approximately 1ng/ml as a capture antibody.
RNAi Knockdown (Antibody validated)
Western blot analysis of CRX over-expressed 293 cell line, cotransfected with CRX Validated Chimera RNAi ( Cat # H00001406-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with CRX monoclonal antibody (M01), clone F6-C2 (Cat # H00001406-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
Western Blot detection against Immunogen (42.5 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant CRX.
Immunogen
CRX (AAH16664, 1 a.a. ~ 300 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MMAYMNPGPHYSVNALALSGPSVDLMHQAVPYPSAPRKQRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKQQQQPPGGQAKARPAKRKAGTSPRPSTDVCPDPLGISDSYSPPLPGPSGSPTTAVATVSIWSPASESPLPEAQRAGLVASGPSLTSAPYAMTYAPASAFCSSPSAYGSPSSYFSGLDPYLSPMVPQLGGPALSPLSGPSVGPSLAQSPTSLSGQSYGAYSPVDSLEFKDPTGTWKFTYNPMDPLDYKDQSAWKFQIL
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (97); Rat (97)
Isotype
IgG1 kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (42.5 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of CRX expression in transfected 293T cell line by CRX monoclonal antibody (M01), clone F6-C2.
Lane 1: CRX transfected lysate(32.261 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged CRX is approximately 1ng/ml as a capture antibody.ELISA
RNAi Knockdown (Antibody validated)
Western blot analysis of CRX over-expressed 293 cell line, cotransfected with CRX Validated Chimera RNAi ( Cat # H00001406-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with CRX monoclonal antibody (M01), clone F6-C2 (Cat # H00001406-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control. -
Gene Info — CRX
Entrez GeneID
1406GeneBank Accession#
BC016664Protein Accession#
AAH16664Gene Name
CRX
Gene Alias
CORD2, CRD, LCA7, OTX3
Gene Description
cone-rod homeobox
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq
Other Designations
cone-rod homeobox protein|orthodenticle homeobox 3
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Interactome
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Disease
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Publication Reference
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Effects of Extracellular Matrix and Neighboring Cells on Induction of Human Embryonic Stem Cells into Retinal or Retinal Pigment Epithelial Progenitors.
Gonga J, Sagiva O, Caia H, Tsanga SH, Del Priore LV.
Experimental Eye Research 2008 Mar; 86(6):957.
Application：IF, Human, Photoreceptor progenitor from ARPE19 cells.
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Effects of Extracellular Matrix and Neighboring Cells on Induction of Human Embryonic Stem Cells into Retinal or Retinal Pigment Epithelial Progenitors.
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