CRHR1 (Human) Recombinant Protein (Q01)
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Specification
Product Description
Human CRHR1 partial ORF ( NP_004373, 24 a.a. - 121 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
SLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVI
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.52
Interspecies Antigen Sequence
Mouse (97); Rat (96)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — CRHR1
Entrez GeneID
1394GeneBank Accession#
NM_004382Protein Accession#
NP_004373Gene Name
CRHR1
Gene Alias
CRF-R, CRF1, CRFR1, CRH-R1h, CRHR, CRHR1f
Gene Description
corticotropin releasing hormone receptor 1
Omim ID
122561Gene Ontology
HyperlinkGene Summary
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants
Other Designations
CRF1 receptor isoform I variant B|corticotropin releasing hormone receptor variant 1h|corticotropin-releasing factor receptor|seven transmembrane helix receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Expression and Role of the CRH/Urocortin-Receptor-Binding Protein (CRH/UCN-R-BP) System in the Primate Corpus Luteum during the Menstrual Cycle.
Xu J, Xu F, Hennebold JD, Molskness TA, Stouffer RL.
Endocrinology 2007 Aug; 148(11):5385.
Application:WB, Monkey, Monkey ovary.
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Expression and Role of the CRH/Urocortin-Receptor-Binding Protein (CRH/UCN-R-BP) System in the Primate Corpus Luteum during the Menstrual Cycle.
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