CRH 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-CRH full-length
Host
Human
Theoretical MW (kDa)
21.67
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-CRH antibody (H00001392-B01) by Western Blots.
SDS-PAGE Gel
CRH transfected lysate.
Western Blot
Lane 1: CRH transfected lysate ( 21.67 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — CRH
Entrez GeneID
1392GeneBank Accession#
NM_000756Protein Accession#
NP_000747Gene Name
CRH
Gene Alias
CRF
Gene Description
corticotropin releasing hormone
Gene Ontology
HyperlinkGene Summary
Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide derived from a 191-amino acid preprohormone. CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in CRH has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin dificiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, CRH is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta CRH is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of CRH occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, CRH may act as a trigger for parturition. [provided by RefSeq
Other Designations
corticotropin-releasing factor
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Interactome
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Pathway
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Disease
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