CREBL2 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
CREBL2 transfected lysate.
Western Blot
Lane 1: CREBL2 transfected lysate ( 13.31 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-CREBL2 full-length
Host
Human
Theoretical MW (kDa)
13.31
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-CREBL2 antibody (H00001389-B01) by Western Blots.
SDS-PAGE Gel
CREBL2 transfected lysate.
Western Blot
Lane 1: CREBL2 transfected lysate ( 13.31 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — CREBL2
Entrez GeneID
1389GeneBank Accession#
NM_001310.2Protein Accession#
-Gene Name
CREBL2
Gene Alias
MGC117311, MGC138362
Gene Description
cAMP responsive element binding protein-like 2
Omim ID
603476Gene Ontology
HyperlinkGene Summary
cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq
Other Designations
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Interactome
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Disease
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