CREBL1 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human CREBL1 full-length ORF ( AAH08394.1, 1 a.a. - 318 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQVKSEPSSPCSSSSLSSESSRLSTEPSSEALGVGEVLHVKTESLAPPLCLLGDDPTSSFETVQINVIPTSDDSSDVQTKIEPVSPCSSVNSEASLLSADSSSQAFIGEEVLEVKTESLSPSGCLLWDVPAPSLGAVQISMGPSLDGSSGKALPTRKPPLQPKPVVLTTVPMPSRAVSPSTTVLLQSLVQPPPGTEEGEKGRAWWLTPVIPALWEAEAGESPEVRSLRPAWPTW
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
60.61
Interspecies Antigen Sequence
Mouse (83); Rat (83)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ATF6B
Entrez GeneID
1388GeneBank Accession#
BC008394.1Protein Accession#
AAH08394.1Gene Name
ATF6B
Gene Alias
CREB-RP, CREBL1, FLJ10066, G13
Gene Description
activating transcription factor 6 beta
Omim ID
600984Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
Creb-related protein|OTTHUMP00000029433|cAMP responsive element binding protein-like 1|cyclic AMP-dependent transcription factor ATF-6 beta|protein G13
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Interactome
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Disease
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