CPT1A (Human) Recombinant Protein (P01)
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Specification
Product Description
Human CPT1A full-length ORF ( NP_001867.2, 1 a.a. - 773 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAEAHQAVAFQFTVTPDGIDLRLSHEALRQIYLSGLHSWKKKFIRFKNGIITGVYPASPSSWLIVVVGVMTTMYAKIDPSLGIIAKINRTLETANCMSSQTKNVVSGVLFGTGLWVALIVTMRYSLKVLLSYHGWMFTEHGKMSRATKIWMGMVKIFSGRKPMLYSFQTSLPRLPVPAVKDTVNRYLQSVRPLMKEEDFKRMTALAQDFAVGLGPRLQWYLKLKSWWATNYVSDWWEEYIYLRGRGPLMVNSNYYAMDLLYILPTHIQAARAGNAIHAILLYRRKLDREEIKPIRLLGSTIPLCSAQWERMFNTSRIPGEETDTIQHMRDSKHIVVYHRGRYFKVWLYHDGRLLKPREMEQQMQRILDNTSEPQPGEARLAALTAGDRVPWARCRQAYFGRGKNKQSLDAVEKAAFFVTLDETEEGYRSEDPDTSMDSYAKSLLHGRCYDRWFDKSFTFVVFKNGKMGLNAEHSWADAPIVAHLWEYVMSIDSLQLGYAEDGHCKGDINPNIPYPTRLQWDIPGECQEVIETSLNTANLLANDVDFHSFPFVAFGKGIIKKCRTSPDAFVQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTTESCDFVRAMVDPAQTVEQRLKLFKLASEKHQHMYRLAMTGSGIDRHLFCLYVVSKYLAVESPFLKEVLSEPWRLSTSQTPQQQVELFDLENNPEYVSSGGGFGPVADDGYGVSYILVGENLINFHISSKFSCPETDSHRFGRHLKEAMTDIITLFGLSSNSKK
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
114.8
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — CPT1A
Entrez GeneID
1374GeneBank Accession#
NM_001876.2Protein Accession#
NP_001867.2Gene Name
CPT1A
Gene Alias
CPT1, CPT1-L, L-CPT1
Gene Description
carnitine palmitoyltransferase 1A (liver)
Gene Ontology
HyperlinkGene Summary
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
carnitine palmitoyltransferase 1A|carnitine palmitoyltransferase I, liver
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Interactome
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Pathway
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Disease
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Publication Reference
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Loss of hepatic miR-33 improves metabolic homeostasis and liver function without altering body weight or atherosclerosis.
Nathan L Price, Xinbo Zhang, Pablo Fernández-Tussy, Abhishek K Singh, Sean A Burnap, Noemi Rotllan, Leigh Goedeke, Jonathan Sun, Alberto Canfrán-Duque, Binod Aryal, Manuel Mayr, Yajaira Suárez, Carlos Fernández-Hernando.
PNAS 2021 Feb; 118(5):e200647811.
Application：WB-Ti, Mouse, Mouse livers.
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Loss of hepatic miR-33 improves metabolic homeostasis and liver function without altering body weight or atherosclerosis.
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