MAP3K8 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human MAP3K8 partial ORF ( NP_005195, 368 a.a. - 467 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
SLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELPENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.74
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — MAP3K8
Entrez GeneID
1326GeneBank Accession#
NM_005204Protein Accession#
NP_005195Gene Name
MAP3K8
Gene Alias
COT, EST, ESTF, FLJ10486, TPL2, Tpl-2, c-COT
Gene Description
mitogen-activated protein kinase kinase kinase 8
Gene Ontology
HyperlinkGene Summary
This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. [provided by RefSeq
Other Designations
Cancer Osaka thyroid oncogene|Ewing sarcoma transformant|OTTHUMP00000019392|OTTHUMP00000019393|cot (cancer Osaka thyroid) oncogene|proto-oncogene serine/threoine protein kinase|tumor progression locus-2
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