CORT (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human CORT full-length ORF ( NP_001293.2, 1 a.a. - 155 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MYRHKNSWRLGLKYPPSSKEETQVPKTLISGLPGRKSSSRVGEKLQSAHKMPLSPGLLLLLLSGATATAALPLEGGPTGRDSEHMQEAAGIRKSSLLTFLAWWFEWTSQASAGPLIGEEAREVARRQEGAPPQQSARRDRMPCRNFFWKTFSSCK
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
43.6
Interspecies Antigen Sequence
Mouse (56); Rat (57)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — CORT
Entrez GeneID
1325GeneBank Accession#
NM_001302.3Protein Accession#
NP_001293.2Gene Name
CORT
Gene Alias
CST-14, CST-17, CST-29
Gene Description
cortistatin
Omim ID
602784Gene Ontology
HyperlinkGene Summary
The product of this gene is a neuropeptide with strong structural similarity to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. [provided by RefSeq
Other Designations
OTTHUMP00000001901|OTTHUMP00000044365|cortistatin-14|cortistatin-17|cortistatin-29|preprocortistatin
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Interactome
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Pathway
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Disease
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