Proximity Ligation Analysis of protein-protein interactions between OSM and COL4A6. HeLa cells were stained with anti-OSM rabbit purified polyclonal 1:1200 and anti-COL4A6 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Two splice variants have been identified for this gene. [provided by RefSeq
OTTHUMP00000023834,OTTHUMP00000023835,collagen IV, alpha-6 polypeptide,collagen alpha 6 type IV,collagen of basement membrane, alpha-6,dJ889N15.4 (Collagen Alpha 6(IV)),type IV alpha 6 collagen