COL1A1 monoclonal antibody (M01), clone 3G3
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant COL1A1.
Immunogen
COL1A1 (NP_000079.1, 1021 a.a. ~ 1108 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
EGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPVGARGPAGPQGPRGDKGETGEQGDRGIK
Host
Mouse
Reactivity
Human, Mouse
Interspecies Antigen Sequence
Mouse (95); Rat (95)
Isotype
IgG3 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (35.42 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
COL1A1 monoclonal antibody (M01), clone 3G3. Western Blot analysis of COL1A1 expression in NIH/3T3(Cat # L018V1 ).Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to COL1A1 on formalin-fixed paraffin-embedded human pancreas. [antibody concentration 3 ug/ml]Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged COL1A1 is 0.03 ng/ml as a capture antibody.ELISA
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Gene Info — COL1A1
Entrez GeneID
1277GeneBank Accession#
NM_000088Protein Accession#
NP_000079.1Gene Name
COL1A1
Gene Alias
OI4
Gene Description
collagen, type I, alpha 1
Gene Ontology
HyperlinkGene Summary
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish
Other Designations
alpha 1 type I collagen|collagen alpha 1 chain type I|collagen of skin, tendon and bone, alpha-1 chain|pro-alpha-1 collagen type 1|type I collagen alpha 1 chain
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Interactome
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Pathway
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Disease
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Publication Reference
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Valproic acid modulates collagen architecture in the postoperative conjunctival scar.
Li-Fong Seet, Stephanie Wl Chu, Li Zhen Toh, Xiao Teng, Gary Hf Yam, Tina T Wong.
Journal of Molecular Medicine (Berlin, Germany) 2022 Jun; 100(6):947.
Application:IF, WB-Ce, Mouse, Mouse conjunctiva.
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A novel biphenyl compound IMB-S7 ameliorates hepatic fibrosis in BDL rats by suppressing Sp1-mediated integrin αv expression.
Zhang N, Zhao SS, Zhang YX, Wang YC, Shao RG, Wang JX, He HW.
Acta Pharmacologica Sinica 2020 May; 41(5):661.
Application:WB-Ce, WB-Ti, WB-Tr, Human, Mouse, Rat, LX2 cells, Mouse hepatic stellate cells, Rat livers.
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Targeted therapy for the post-operative conjunctiva: SPARC silencing reduces collagen deposition.
Seet LF, Tan YF, Toh LZ, Chu SW, Lee YS, Venkatraman SS, Wong TT.
The British Journal of Ophthalmology 2018 Jul; [Epub].
Application:WB-Ti, Mouse, Mouse conjunctival tissues.
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Bevacizumab Promotes T-Cell-Mediated Collagen Deposition in the Mouse Model of Conjunctival Scarring.
Seet LF, Toh LZ, Chu S, Finger SN, Ginhoux F, Hong W, Wong TT.
Investigative Ophthalmology & Visual science 2018 Mar; 59(3):1682.
Application:WB, Mouse, Eye.
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Valproic acid modulates collagen architecture in the postoperative conjunctival scar.
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