CNR2 monoclonal antibody (M01), clone 3C7
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant CNR2.
Immunogen
CNR2 (NP_001832.1, 302 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
RSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (74); Rat (66)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (32.12 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of CNR2 expression in transfected 293T cell line by CNR2 monoclonal antibody (M01), clone 3C7.
Lane 1: CNR2 transfected lysate(39.7 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged CNR2 is 0.1 ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to CNR2 on HeLa cell . [antibody concentration 10 ug/ml] -
Gene Info — CNR2
Entrez GeneID
1269GeneBank Accession#
NM_001841.1Protein Accession#
NP_001832.1Gene Name
CNR2
Gene Alias
CB2, CX5
Gene Description
cannabinoid receptor 2 (macrophage)
Omim ID
605051Gene Ontology
HyperlinkGene Summary
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq
Other Designations
OTTHUMP00000015772|OTTHUMP00000044841
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Interactome
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Pathway
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Disease
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Publication Reference
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Cannabinoid receptor 2 expression in early-stage non-small cell lung cancers identifies patients with good prognosis and longer survival.
Monika Vidlarova, Emil Berta, Petr Prasil, Andrea Prokopova, Sona Gurska, Marta Khoylou, Alona Rehulkova, Pavla Kourilova, Josef Chudacek, Marek Szkorupa, Jiri Klein, Jozef Skarda, Josef Srovnal, Marian Hajduch.
Translational Lung Cancer Research 2022 Oct; 11(10):2040.
Application:IHC, Human, Non-small cell lung cancer tissue.
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Ontogeny and programming of the fetal temporal cortical endocannabinoid system by moderate maternal nutrient reduction in baboons (Papio spp.).
Gandhi K, Montoya-Uribe V, Martinez S, David S, Jain B, Shim G, Li C, Jenkins S, Nathanielsz P, Schlabritz-Loutsevitch N.
Physiological Reports 2019 Mar; 7(6):e14024.
Application:WB, Baboons, Fetuses.
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Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp.) of obesity.
Brocato B, Zoerner AA, Janjetovic Z, Skobowiat C, Gupta S, Moore Ii BM, Slominski A, Zhang J, Schenone M, Phinehas R, Ferry RJ Jr, Dick E Jr, Hubbard GB, Mari G, Schlabritz-Loutsevitch N.
Placenta 2013 Nov; 34(11):983.
Application:IHC-P, WB-Ti, Baboon, Placenta.
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Cannabinoid receptor 2 expression in early-stage non-small cell lung cancers identifies patients with good prognosis and longer survival.
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