CCR5 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-CCR5 full-length
Host
Human
Theoretical MW (kDa)
40.5
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-CCR5 antibody (H00001234-D01P) by Western Blots.
SDS-PAGE Gel
CCR5 transfected lysate.
Western Blot
Lane 1: CCR5 transfected lysate ( 40.50 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — CCR5
Entrez GeneID
1234GeneBank Accession#
NM_000579Protein Accession#
XP_001125981.1Gene Name
CCR5
Gene Alias
CC-CKR-5, CCCKR5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
Gene Description
chemokine (C-C motif) receptor 5
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
C-C chemokine receptor 5|C-C chemokine receptor type 5|CCR5 chemokine receptor|chemokine (C-C) receptor 5|chemokine receptor CCR5|chemr13
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Interactome
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Disease
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