Western blot analysis of CLK3 over-expressed 293 cell line, cotransfected with CLK3 Validated Chimera RNAi ( Cat # H00001198-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with CLK3 monoclonal antibody (M05) clone 1F10 (Cat # H00001198-M05 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq