CLCA1 monoclonal antibody (M02), clone 1C4
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant CLCA1.
Immunogen
CLCA1 (NP_001276, 677 a.a. ~ 776 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
ALGGVNAARRRVIPQQSGALYIPGWIENDEIQWNPPRPEINKDDVQHKQVCFSRTSSGGSFVASDVPNAPIPDLFPPGQITDLKAEIHGGSLINLTWTAP
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (66); Rat (69)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged CLCA1 is 0.3 ng/ml as a capture antibody.ELISA
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Gene Info — CLCA1
Entrez GeneID
1179GeneBank Accession#
NM_001285Protein Accession#
NP_001276Gene Name
CLCA1
Gene Alias
CACC, CACC1, CLCRG1, FLJ95147, GOB5
Gene Description
chloride channel regulator 1
Omim ID
603906Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq
Other Designations
CLCA family member 1, chloride channel regulator|OTTHUMP00000011907|calcium-activated chloride channel protein 1|calcium-dependent chloride channel-1|chloride channel, calcium activated, family member 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Profiling of differentially expressed proteins in stage IV colorectal cancers with good and poor outcomes.
Kim HJ, Kang UB, Lee H, Jung JH, Lee ST, Yu MH, Kim H, Lee C.
Journal of Proteomics 2012 Jun; 75(10):2983.
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Profiling of differentially expressed proteins in stage IV colorectal cancers with good and poor outcomes.
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