ERCC8 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human ERCC8 full-length ORF (AAH09793.1, 1 a.a. - 205 a.a.) recombinant protein with GST tag at N-terminal.
Sequence
MLGFLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGIFILFQTATTLSKRFNKKKRY
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
48.29
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ERCC8
Entrez GeneID
1161GeneBank Accession#
BC009793.1Protein Accession#
AAH09793.1Gene Name
ERCC8
Gene Alias
CKN1, CSA
Gene Description
excision repair cross-complementing rodent repair deficiency, complementation group 8
Gene Ontology
HyperlinkGene Summary
This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. [provided by RefSeq
Other Designations
Cockayne syndrome WD-repeat protein CSA|DNA excision repair protein ERCC-8
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Interactome
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Pathway
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Disease
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