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Last updated: 2016/12/4

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CHRNA4 rabbit monoclonal antibody

  • Catalog # : H00001137-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human CHRNA4 peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human CHRNA4 is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human CHRNA4 peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 1137
  • Gene Name:
  • CHRNA4
  • Gene Alias:
  • BFNC,EBN,EBN1,FLJ95812,NACHR,NACHRA4,NACRA4
  • Gene Description:
  • cholinergic receptor, nicotinic, alpha 4
  • Gene Summary:
  • This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. [provided by RefSeq
  • Other Designations:
  • cholinergic receptor, nicotinic, alpha 4 subunit,cholinergic receptor, nicotinic, alpha polypeptide 4,neuronal nicotinic acetylcholine receptor alpha-4 subunit
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