LYST monoclonal antibody (M07), clone 3H1
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant LYST.
Immunogen
LYST (NP_000072.2, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNSIIDQALTCREELLTLLLSLLPLVWKIPVQEEKATDFNLPL
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (95); Rat (93)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged LYST is 0.03 ng/ml as a capture antibody.ELISA
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Gene Info — LYST
Entrez GeneID
1130GeneBank Accession#
NM_000081Protein Accession#
NP_000072.2Gene Name
LYST
Gene Alias
CHS, CHS1
Gene Description
lysosomal trafficking regulator
Gene Ontology
HyperlinkGene Summary
This gene is thought to encode a protein that regulates intracellular protein trafficking to and from the lysosome. Mutations in this gene are associated with Chediak-Higashi syndrome, a rare lysosomal storage disorder. Alternatively spliced transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq
Other Designations
Chediak-Higashi syndrome 1|OTTHUMP00000059294|beige protein
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Interactome
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Publication Reference
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Chediak-Higashi syndrome: description of two novel homozygous missense mutations causing divergent clinical phenotype.
Sanchez-Guiu I, Anton AI, Garcia-Barbera N, Navarro-Fernandez J, Martinez C, Fuster JL, Couselo JM, Ortuno FJ, Vicente V, Rivera J, Lozano ML.
European Journal of Haematology 2014 Jan; 92(1):49.
Application:WB-Ce, Human, Skin fibroblasts.
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Chediak-Higashi syndrome: description of two novel homozygous missense mutations causing divergent clinical phenotype.
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