CHIT1 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human CHIT1 peptide using ARM Technology.
Immunogen
A synthetic peptide of human CHIT1 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human CHIT1 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — CHIT1
Entrez GeneID
1118GeneBank Accession#
CHIT1Gene Name
CHIT1
Gene Alias
CHI3, CHIT, FLJ00314, MGC125322
Gene Description
chitinase 1 (chitotriosidase)
Omim ID
600031Gene Ontology
HyperlinkGene Summary
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. [provided by RefSeq
Other Designations
chitotriosidase|plasma methylumbelliferyl tetra-N-acetylchitotetraoside hydrolase
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