CTSC 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-CTSC full-length
Host
Human
Theoretical MW (kDa)
51.8
Interspecies Antigen Sequence
Mouse (78); Rat (80)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-CTSC antibody (H00001075-D01P) by Western Blots.
SDS-PAGE Gel
CTSC transfected lysate.
Western Blot
Lane 1: CTSC transfected lysate ( 51.80 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — CTSC
Entrez GeneID
1075GeneBank Accession#
NM_001814Protein Accession#
NP_001805.1Gene Name
CTSC
Gene Alias
CPPI, DPP1, DPPI, HMS, JP, JPD, PALS, PLS
Gene Description
cathepsin C
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
cathepsin J|dipeptidyl transferase|dipeptidyl-peptidase I
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Interactome
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Pathway
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Disease
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