Products

Western Blot (Transfected lysate)

Immunofluorescence (Transfected cell)

Flow Cytometry (Transfected cell)

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

CES1

Gene Alias

ACAT, CEH, CES2, HMSE, HMSE1, MGC117365, PCE-1, SES1, TGH

Gene Description

carboxylesterase 1 (monocyte/macrophage serine esterase 1)

Omim ID

Gene Ontology

Gene Summary

Carboxylesterase 1 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolize long-chain fatty acid esters and thioesters. This enzyme is known to hydrolyze aromatic and aliphatic esters and is necessary for cellular cholesterol esterification. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds. Carboxylesterase deficiency may be associated with non-Hodgkin lymphoma or B-cell lymphocytic leukemia. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq

Other Designations

acyl coenzyme A:cholesterol acyltransferase|carboxylesterase 1|carboxylesterase 2 (liver)|cholesteryl ester hydrolase|egasyn|liver carboxylesterase|triacylglycerol hydrolase