Immunoprecipitation of CENPB transfected lysate using anti-CENPB MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with CENPB purified MaxPab mouse polyclonal antibody (B01P) (H00001059-B01P).
This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. [provided by RefSeq
OTTHUMP00000030132,centromere autoantigen B,centromere protein B,centromere protein B (80kD)