CEBPB (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human CEBPB full-length ORF ( AAH21931.1, 1 a.a. - 345 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MQRLVAWDPACLPLPPPPPAFKSMEVANFYYEADCLAAAYGGKAAPAAPPAARPGPRPPAGELGSIGDHERAIDFSPYLEPLGAPQAPAPATATDTFEAAPPAPAPAPASSGQHHDFLSDLFSDDYGGKNCKKPAEYGYVSLGRLGAAKGALHPGCFAPLHPPPPPPPPPAELKAEPGFEPADCKRKEEAGAPGGGAGMAAGFPYALRAYLGYQAVPSGSSGSLSTSSSSSPPGTPSPADAKAPPTACYAGAAPAPSQVKSKAKKTVDKHSDEYKIRRERNNIAVRKSRDKAKMRNLETQHKVLELTAENERLQKKVEQLSRELSTLRNLFKQLPEPLLASSGHC
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
62.5
Interspecies Antigen Sequence
Mouse (66); Rat (66)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — CEBPB
Entrez GeneID
1051GeneBank Accession#
BC021931.1Protein Accession#
AAH21931.1Gene Name
CEBPB
Gene Alias
C/EBP-beta, CRP2, IL6DBP, LAP, MGC32080, NF-IL6, TCF5
Gene Description
CCAAT/enhancer binding protein (C/EBP), beta
Omim ID
189965Gene Ontology
HyperlinkGene Summary
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. [provided by RefSeq
Other Designations
CCAAT/enhancer binding protein beta|interleukin 6-dependent DNA-binding protein|liver-enriched transcriptional activator protein|nuclear factor of interleukin 6|transcription factor 5
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Interactome
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Disease
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Publication Reference
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Tumor necrosis factor-alpha induces expression of C/EBP-beta in primary afferent neurons following nerve injury.
Sasaki M, Hashimoto S, Sawa T, Amaya F.
Neuroscience 2014 Oct; 279:1.
Application：WB-Re, Rat, Neuron.
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Tumor necrosis factor-alpha induces expression of C/EBP-beta in primary afferent neurons following nerve injury.
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