CDKN2C 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-CDKN2C full-length
Host
Human
Theoretical MW (kDa)
18.59
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-CDKN2C antibody (H00001031-B02) by Western Blots.
Western Blot
Lane 1: CDKN2C transfected lysate ( 18.1 KDa)
Lane 2: Non-transfected lysate.SDS-PAGE Gel
CDKN2C transfected lysate.
Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — CDKN2C
Entrez GeneID
1031GeneBank Accession#
NM_001262Protein Accession#
NP_001253Gene Name
CDKN2C
Gene Alias
INK4C, p18, p18-INK4C
Gene Description
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
Omim ID
603369Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq
Other Designations
CDK6 inhibitor p18|OTTHUMP00000009730|OTTHUMP00000009731|OTTHUMP00000046546|cyclin-dependent inhibitor|cyclin-dependent kinase 4 inhibitor C|cyclin-dependent kinase 6 inhibitor p18|cyclin-dependent kinase inhibitor 2C
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Interactome
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Pathway
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Disease
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