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CDKN2C rabbit monoclonal antibody

  • Catalog # : H00001031-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human CDKN2C peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human CDKN2C is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human CDKN2C peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 1031
  • Gene Name:
  • CDKN2C
  • Gene Alias:
  • INK4C,p18,p18-INK4C
  • Gene Description:
  • cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
  • Gene Summary:
  • The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq
  • Other Designations:
  • CDK6 inhibitor p18,OTTHUMP00000009730,OTTHUMP00000009731,OTTHUMP00000046546,cyclin-dependent inhibitor,cyclin-dependent kinase 4 inhibitor C,cyclin-dependent kinase 6 inhibitor p18,cyclin-dependent kinase inhibitor 2C
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