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CDKN2B rabbit monoclonal antibody

  • Catalog # : H00001030-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human CDKN2B peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human CDKN2B is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human CDKN2B peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 1030
  • Gene Name:
  • CDKN2B
  • Gene Alias:
  • CDK4I,INK4B,MTS2,P15,TP15,p15INK4b
  • Gene Description:
  • cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
  • Gene Summary:
  • This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq
  • Other Designations:
  • CDK inhibitory protein,CDK4B inhibitor,OTTHUMP00000021154,OTTHUMP00000021155,cyclin-dependent kinase 4 inhibitor B,cyclin-dependent kinase inhibitor 2B,cyclin-dependent kinases 4 and 6 binding protein,multiple tumor suppressor 2,p14_CDK inhibitor,p14_INK4
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