Western blot analysis of CDH6 over-expressed 293 cell line, cotransfected with CDH6 Validated Chimera RNAi ( Cat # H00001004-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with CDH6 monoclonal antibody (M05), clone 2F2 (Cat # H00001004-M05 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion. [provided by RefSeq