CD97 polyclonal antibody (A01)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant CD97.
Immunogen
CD97 (NP_510966, 421 a.a. ~ 529 a.a) partial recombinant protein with GST tag.
Sequence
KKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAGRDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSH
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (38); Rat (35)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (38.1 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — CD97
Entrez GeneID
976GeneBank Accession#
NM_078481Protein Accession#
NP_510966Gene Name
CD97
Gene Alias
TM7LN1
Gene Description
CD97 molecule
Omim ID
601211Gene Ontology
HyperlinkGene Summary
This gene is a member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules, likely encoded by a gene cluster on the short arm of chromosome 19. The encoded product is a glycoprotein that is present on the surface of most activated leukocytes and spans the membrane seven times, which is a defining feature of G protein-coupled receptors. The protein has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to its cellular ligand, decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade. The presence of structural features characteristic of extracellular matrix proteins and transmembrane proteins suggests that this protein is a receptor involved in both cell adhesion and signaling processes early after leukocyte activation. Alternative splicing has been observed for this gene and three variants have been found. [provided by RefSeq
Other Designations
CD97 antigen|leukocyte antigen CD97|seven transmembrane helix receptor|seven-span transmembrane protein|seven-transmembrane, heterodimeric receptor associated with inflammation
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Interactome
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Disease
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Publication Reference
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Effects of targeted CD97 immune epitopes small interference RNA on cellular biological behaviors in MDA-MB231 malignant breast cancer cell line.
Tian H, Chen Y, Zhao JG, Liu DR, Gong WH, Chen L, Wu YL, Wang JA.
American Journal of Translational Research 2017 Oct; 9(10):4640.
Application:WB-Ce, Human, MCF-7, MDA-MB231, MDA-468, T47D cells.
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The invasion and metastasis promotion role of CD97 small isoform in gastric carcinoma.
Liu D, Trojanowicz B, Ye L, Li C, Zhang L, Li X, Li G, Zheng Y, Chen L.
PLoS One 2012 Jun; 7(6):e39989.
Application:WB, Human, AGS, BGC-823, MGC-801, SGC-7901 cells.
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Effects of targeted CD97 immune epitopes small interference RNA on cellular biological behaviors in MDA-MB231 malignant breast cancer cell line.
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