CCND2 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
CCND2 transfected lysate.
Western Blot
Lane 1: CCND2 transfected lysate ( 33.10 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-CCND2 full-length
Host
Human
Theoretical MW (kDa)
33.1
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-CCND2 antibody (H00000894-D01) by Western Blots.
SDS-PAGE Gel
CCND2 transfected lysate.
Western Blot
Lane 1: CCND2 transfected lysate ( 33.10 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — CCND2
Entrez GeneID
894GeneBank Accession#
NM_001759Protein Accession#
NP_001750.1Gene Name
CCND2
Gene Alias
KIAK0002, MGC102758
Gene Description
cyclin D2
Omim ID
123833Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. [provided by RefSeq
Other Designations
G1/S-specific cyclin D2
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Interactome
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Pathway
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Disease
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