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Last updated: 2016/10/23
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KRIT1 monoclonal antibody (M02), clone 1D8

  • Catalog # : H00000889-M02
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against a partial recombinant KRIT1.
  • Immunogen:
  • KRIT1 (NP_004903, 637 a.a. ~ 736 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
  • Sequence:
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Isotype:
  • IgG1 Kappa
  • Quality Control Testing:
  • Antibody Reactive Against Recombinant Protein.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Sandwich ELISA (Recombinant protein)
  • Sandwich ELISA (Recombinant protein)
  • Detection limit for recombinant GST tagged KRIT1 is 0.1 ng/ml as a capture antibody.
  • PDF DownloadProtocol Download
  • Application Image
  • Sandwich ELISA (Recombinant protein)
  • Sandwich ELISA (Recombinant protein)
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  • Gene Information
  • Entrez GeneID:
  • 889
  • Gene Name:
  • KRIT1
  • Gene Alias:
  • CAM,CCM1
  • Gene Description:
  • KRIT1, ankyrin repeat containing
  • Gene Summary:
  • This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq
  • Other Designations:
  • ankyrin repeat-containing protein Krit1,cerebral cavernous malformations 1,krev interaction trapped 1
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