CBR3 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human CBR3 partial ORF ( NP_001227, 180 a.a. - 277 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTVEEGAETPVYLALLPPDATEPQGQLVHDKVVQNW
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.52
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — CBR3
Entrez GeneID
874GeneBank Accession#
NM_001236Protein Accession#
NP_001227Gene Name
CBR3
Gene Alias
SDR21C2, hCBR3
Gene Description
carbonyl reductase 3
Omim ID
603608Gene Ontology
HyperlinkGene Summary
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq
Other Designations
NADPH-dependent carbonyl reductase 3|carbonyl reductase (NADPH) 3|short chain dehydrogenase/reductase family 21C, member 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Naturally Occurring Variants of Human CBR3 Alter Anthracycline In Vitro Metabolism.
Bains OS, Karkling MJ, Lubieniecka JM, Grigliatti TA, Reid RE, Riggs KW.
The Journal of Pharmacology and Experimental Therapeutics 2010 Mar; 332(3):755.
Application:WB, Escherichia coli, BL21 (DE3) pLysS competent cells.
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Naturally Occurring Variants of Human CBR3 Alter Anthracycline In Vitro Metabolism.
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