CBR1 monoclonal antibody (M02), clone 4D12-1G8
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant CBR1.
Immunogen
CBR1 (AAH02511.1, 1 a.a. ~ 277 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
Host
Mouse
Reactivity
Human
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (56.21 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
CBR1 monoclonal antibody (M02), clone 4D12-1G8 Western Blot analysis of CBR1 expression in Hela ( Cat # L013V1 ).Western Blot (Recombinant protein)
ELISA
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Gene Info — CBR1
Entrez GeneID
873GeneBank Accession#
BC002511Protein Accession#
AAH02511.1Gene Name
CBR1
Gene Alias
CBR, SDR21C1, hCBR1
Gene Description
carbonyl reductase 1
Omim ID
114830Gene Ontology
HyperlinkGene Summary
Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues. Another carbonyl reductase gene, CRB3, lies close to this gene on chromosome 21q. [provided by RefSeq
Other Designations
carbonyl reductase (NADPH) 1|prostaglandin 9-ketoreductase|prostaglandin-E(2) 9-reductase|short chain dehydrogenase/reductase family 21C, member 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Carbonyl reductase 1 protects pancreatic ss-cells against oxidative stress-induced apoptosis in glucotoxicity and glucolipotoxicity.
Rashid MA, Lee S, Tak E, Lee J, Choi TG, Lee JW, Kim JB, Youn JH, Kang I, Ha J, Kim SS.
Free Radical Biology & Medicine 2018 Dec; 129:614.
Application:WB-Ti, Mouse, Mouse pancreatic islets.
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Functional characterization of the promoter of human carbonyl reductase 1 (CBR1). Role of XRE elements in mediating induction of CBR1 by ligands of the aryl hydrocarbon receptor.
Lakhman SS, Chen X, Gonzalez-Covarrubias V, Schuetz EG, Blanco JG.
Molecular Pharmacology 2007 Jun; 72(3):734.
Application:WB-Ti, Mouse, Mouse liver.
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Carbonyl reductase 1 protects pancreatic ss-cells against oxidative stress-induced apoptosis in glucotoxicity and glucolipotoxicity.
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