CBFA2T3 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human CBFA2T3 peptide using ARM Technology.
Immunogen
A synthetic peptide of human CBFA2T3 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human CBFA2T3 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — CBFA2T3
Entrez GeneID
863GeneBank Accession#
CBFA2T3Gene Name
CBFA2T3
Gene Alias
ETO2, MTG16, MTGR2, ZMYND4
Gene Description
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
Omim ID
603870Gene Ontology
HyperlinkGene Summary
The t(16;21)(q24;q22) translocation is a rare but recurrent chromosomal abnormality associated with therapy-related myeloid malignancies. The translocation produces a chimeric gene made up of the 5'-region of the AML1 gene fused to the 3'-region of this gene. In addition, this gene is a putative breast tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene, and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi apparatus. [provided by RefSeq
Other Designations
MTG8-related gene 2|myeloid translocation gene on chromosome 16|zinc finger MYND domain-containing protein 4
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Interactome
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