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CAV1 rabbit monoclonal antibody

  • Catalog # : H00000857-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human CAV1 peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human CAV1 is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human CAV1 peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 857
  • GeneBank Accession#:
  • CAV1
  • Gene Name:
  • CAV1
  • Gene Alias:
  • BSCL3,CAV,CGL3,MSTP085,VIP21
  • Gene Description:
  • caveolin 1, caveolae protein, 22kDa
  • Gene Summary:
  • The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000025031,caveolae protein, 22-kD,caveolin 1,caveolin 1 caveolae protein, 22kD,caveolin 1, alpha isoform,caveolin 1, beta isoform,caveolin-1 beta isoform protein,cell growth-inhibiting protein 32
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