CASP4 monoclonal antibody (M02), clone 7G7
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More Files
- More Functions
Western Blot (Cell lysate)
CASP4 monoclonal antibody (M02), clone 7G7. Western Blot analysis of CASP4 expression in HeLa.
Western Blot (Transfected lysate)
Western Blot analysis of CASP4 expression in transfected 293T cell line by CASP4 monoclonal antibody (M02), clone 7G7.
Lane 1: CASP4 transfected lysate (Predicted MW: 43.3 KDa).
Lane 2: Non-transfected lysate.
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged CASP4 is 0.03 ng/ml as a capture antibody.
Western Blot detection against Immunogen (67.21 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant CASP4.
Immunogen
CASP4 (AAH17839, 1 a.a. ~ 377 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (60); Rat (59)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (67.21 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
CASP4 monoclonal antibody (M02), clone 7G7. Western Blot analysis of CASP4 expression in HeLa.Western Blot (Transfected lysate)
Western Blot analysis of CASP4 expression in transfected 293T cell line by CASP4 monoclonal antibody (M02), clone 7G7.
Lane 1: CASP4 transfected lysate (Predicted MW: 43.3 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged CASP4 is 0.03 ng/ml as a capture antibody.ELISA
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Gene Info — CASP4
Entrez GeneID
837GeneBank Accession#
BC017839Protein Accession#
AAH17839Gene Name
CASP4
Gene Alias
ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX
Gene Description
caspase 4, apoptosis-related cysteine peptidase
Omim ID
602664Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
apoptotic cysteine protease Mih1/TX|caspase 4|caspase 4, apoptosis-related cysteine protease
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Interactome
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Disease
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