CASP4 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human CASP4 peptide using ARM Technology.
Immunogen
A synthetic peptide of human CASP4 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human CASP4 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — CASP4
Entrez GeneID
837GeneBank Accession#
CASP4Gene Name
CASP4
Gene Alias
ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX
Gene Description
caspase 4, apoptosis-related cysteine peptidase
Omim ID
602664Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
apoptotic cysteine protease Mih1/TX|caspase 4|caspase 4, apoptosis-related cysteine protease
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Interactome
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Disease
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