CASP2 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human CASP2 peptide using ARM Technology.
Immunogen
A synthetic peptide of human CASP2 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human CASP2 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — CASP2
Entrez GeneID
835GeneBank Accession#
CASP2Gene Name
CASP2
Gene Alias
CASP-2, ICH-1L, ICH-1L/1S, ICH1, NEDD2
Gene Description
caspase 2, apoptosis-related cysteine peptidase
Omim ID
600639Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The proteolytic cleavage of this protein is induced by a variety of apoptotic stimuli. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq
Other Designations
ICH-1 protease|NEDD2 apoptosis regulatory|caspase 2|neural precursor cell expressed, developmentally down-regulated 2
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Interactome
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Disease
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