TSPO (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human TSPO full-length ORF ( AAH01110.1, 1 a.a. - 169 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAMGYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAAATTVAWYQVSPLAARLLYPYLAWLAFATTLNYCVWRDNHGWHGGRRLPE
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
44.33
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — TSPO
Entrez GeneID
706GeneBank Accession#
BC001110Protein Accession#
AAH01110.1Gene Name
TSPO
Gene Alias
BZRP, DBI, IBP, MBR, PBR, PKBS, PTBR, mDRC, pk18
Gene Description
translocator protein (18kDa)
Omim ID
109610Gene Ontology
HyperlinkGene Summary
Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
OTTHUMP00000028891|benzodiazepine peripheral binding site|mitochondrial benzodiazepine receptor|peripheral benzodiazepine receptor|peripheral-type benzodiazepine receptor|translocator protein
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Interactome
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Pathway
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Disease
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Publication Reference
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The anxiolytic effect of koumine on a predatory sound stress-induced anxiety model and its associated molecular mechanisms.
Bojun Xiong, Zhifeng Zhong, Chaojie Chen, Huihui Huang, Jinxiang Lin, Ying Xu, Jian Yang, Changxi Yu.
Phytomedicine 2022 Aug; 103:154225.
Application：SPR, Chemical .
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Tumor mitochondria-targeted photodynamic therapy with a translocator protein (TSPO)-specific photosensitizer.
Zhang S, Yang L, Ling X, Shao P, Wang X, Edwards WB, Bai M.
Acta Biomaterialia 2015 Dec; 28:160.
Application：Func, IR700DX-6T Compound.
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The anxiolytic effect of koumine on a predatory sound stress-induced anxiety model and its associated molecular mechanisms.
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