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BRCA2 Pre-design Chimera RNAi

  • Catalog # : H00000675-R01
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Homo sapiens breast cancer 2, early onset (BRCA2), mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_000059
  • Target Region:
  • Coding sequence
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Entrez GeneID:
  • 675
  • Gene Name:
  • BRCA2
  • Gene Alias:
  • BRCC2,FACD,FAD,FAD1,FANCB,FANCD,FANCD1
  • Gene Description:
  • breast cancer 2, early onset
  • Gene Summary:
  • Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq
  • Other Designations:
  • BRCA1/BRCA2-containing complex, subunit 2,OTTHUMP00000018803,OTTHUMP00000042401,breast and ovarian cancer susceptibility gene, early onset,breast cancer 2 tumor suppressor,breast cancer susceptibility protein BRCA2
  • Related Disease
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