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BRCA2 (Human) Recombinant Protein (Q01)

  • Catalog # : H00000675-Q01
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Human BRCA2 partial ORF ( NP_000050, 3319 a.a. - 3418 a.a.) recombinant protein with GST-tag at N-terminal.
  • Sequence:
  • SPQMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEKQFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTKKYI
  • Host:
  • Wheat Germ (in vitro)
  • Theoretical MW (kDa):
  • 36.63
  • Purification:
  • Glutathione Sepharose 4 Fast Flow
  • Quality Control Testing:
  • 12.5% SDS-PAGE Stained with Coomassie Blue.

    QC Testing of H00000675-Q01
  • Storage Buffer:
  • 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Best use within three months from the date of receipt of this protein.
  • Publication Reference
  • Applications
  • Enzyme-linked Immunoabsorbent Assay
  • Western Blot (Recombinant protein)
  • Antibody Production
  • Protein Array
  • Application Image
  • Enzyme-linked Immunoabsorbent Assay
  • Western Blot (Recombinant protein)
  • Antibody Production
  • Protein Array
  • Gene Information
  • Entrez GeneID:
  • 675
  • Gene Name:
  • BRCA2
  • Gene Alias:
  • BRCC2,FACD,FAD,FAD1,FANCB,FANCD,FANCD1
  • Gene Description:
  • breast cancer 2, early onset
  • Gene Summary:
  • Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq
  • Other Designations:
  • BRCA1/BRCA2-containing complex, subunit 2,OTTHUMP00000018803,OTTHUMP00000042401,breast and ovarian cancer susceptibility gene, early onset,breast cancer 2 tumor suppressor,breast cancer susceptibility protein BRCA2
  • Related Disease
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