BRCA2 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human BRCA2 partial ORF ( NP_000050, 3319 a.a. - 3418 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
SPQMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEKQFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTKKYI
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.63
Interspecies Antigen Sequence
Mouse (48); Rat (50)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — BRCA2
Entrez GeneID
675GeneBank Accession#
NM_000059Protein Accession#
NP_000050Gene Name
BRCA2
Gene Alias
BRCC2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1
Gene Description
breast cancer 2, early onset
Gene Ontology
HyperlinkGene Summary
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq
Other Designations
BRCA1/BRCA2-containing complex, subunit 2|OTTHUMP00000018803|OTTHUMP00000042401|breast and ovarian cancer susceptibility gene, early onset|breast cancer 2 tumor suppressor|breast cancer susceptibility protein BRCA2
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Interactome
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Pathway
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Disease
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Publication Reference
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Prediction of breast cancer risk based on flow-variant analysis of circulating peripheral blood B cells.
Syeda MM, Upadhyay K, Loke J, Pearlman A, Klugman S, Shao Y, Ostrer H.
Genetics in Medicine : Official Journal of the American College of Medical Genetics 2017 Mar; [Epub].
Application:Flow, Human, EBV-immortalized lymphoblastoid cell lines and B cells.
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Prediction of breast cancer risk based on flow-variant analysis of circulating peripheral blood B cells.
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