BCR 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-BCR full-length
Host
Human
Theoretical MW (kDa)
118.47
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-BCR antibody (H00000613-B01) by Western Blots.
SDS-PAGE Gel
BCR transfected lysate.
Western Blot
Lane 1: BCR transfected lysate ( 118.47 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — BCR
Entrez GeneID
613GeneBank Accession#
BC066122.1Protein Accession#
AAH66122.1Gene Name
BCR
Gene Alias
ALL, BCR-ABL1, BCR1, CML, D22S11, D22S662, FLJ16453, PHL
Gene Description
breakpoint cluster region
Gene Ontology
HyperlinkGene Summary
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
bcr-abl1 e14a3 chimeric protein
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Interactome
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Pathway
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Disease
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