ATP7B (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human ATP7B partial ORF ( NP_000044, 1372 a.a. - 1465 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
QLKCYKKPDLERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTSDKPSRHSAAADDDGDKWSLLLNGRDEEQYI
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.08
Interspecies Antigen Sequence
Mouse (85); Rat (84)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ATP7B
Entrez GeneID
540GeneBank Accession#
NM_000053Protein Accession#
NP_000044Gene Name
ATP7B
Gene Alias
PWD, WC1, WD, WND
Gene Description
ATPase, Cu++ transporting, beta polypeptide
Gene Ontology
HyperlinkGene Summary
This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). [provided by RefSeq
Other Designations
ATPase, Cu(2+)- transporting, beta polypeptide|OTTHUMP00000040880|Wilson disease-associated protein|copper pump 2|copper-transporting ATPase 2
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Interactome
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Disease
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