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Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

ATP6V0C

Gene Alias

ATP6C, ATP6L, ATPL, VATL, Vma3

Gene Description

ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c

Omim ID

Gene Ontology

Gene Summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the V0 domain. This gene had the previous symbols of ATP6C and ATP6L. [provided by RefSeq

Other Designations

ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD|ATPase, H+ transporting, lysosomal 16kD, V0 subunit c|ATPase, H+ transporting, lysosomal, 16-KD|ATPase, H+ transporting, lysosomal, V0 subunit c|H(+)-transporting two-sector ATPase, 16 kDa sub