ATP6V0C (Human) Recombinant Protein (P01)
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Specification
Product Description
Human ATP6V0C full-length ORF ( NP_001685.1, 1 a.a. - 155 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MSESKSGPEYASFFAVMGASAAMVFSALGAAYGTAKSGTGIAAMSVMRPEQIMKSIIPVVMAGIIAIYGLVVAVLIANSLNDDISLYKSFLQLGAGLSVGLSGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILSTK
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
42.1
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ATP6V0C
Entrez GeneID
527GeneBank Accession#
NM_001694.2Protein Accession#
NP_001685.1Gene Name
ATP6V0C
Gene Alias
ATP6C, ATP6L, ATPL, VATL, Vma3
Gene Description
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
Omim ID
108745Gene Ontology
HyperlinkGene Summary
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the V0 domain. This gene had the previous symbols of ATP6C and ATP6L. [provided by RefSeq
Other Designations
ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD|ATPase, H+ transporting, lysosomal 16kD, V0 subunit c|ATPase, H+ transporting, lysosomal, 16-KD|ATPase, H+ transporting, lysosomal, V0 subunit c|H(+)-transporting two-sector ATPase, 16 kDa sub
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