ATP6V1B1 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-ATP6V1B1 full-length
Host
Human
Theoretical MW (kDa)
56.8
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-ATP6V1B1 antibody (H00000525-D01P) by Western Blots.
SDS-PAGE Gel
ATP6V1B1 transfected lysate.
Western Blot
Lane 1: ATP6V1B1 transfected lysate ( 56.80 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — ATP6V1B1
Entrez GeneID
525GeneBank Accession#
NM_001692.3Protein Accession#
NP_001683.2Gene Name
ATP6V1B1
Gene Alias
ATP6B1, MGC32642, RTA1B, VATB, VMA2, VPP3
Gene Description
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
Gene Ontology
HyperlinkGene Summary
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness. [provided by RefSeq
Other Designations
H(+)-transporting two-sector ATPase, 58kD subunit|H+-ATPase beta 1 subunit|V-ATPase B1 subunit|endomembrane proton pump 58 kDa subunit|vacuolar proton pump 3|vacuolar proton pump, subunit 3
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