ATP6V1B1 (Human) Recombinant Protein (Q01)
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Specification
Product Description
Human ATP6V1B1 partial ORF ( NP_001683.2, 1 a.a. - 75 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAMEIDSRPGGLPGSSCNLGAAREHMQAVTRNYITHPRVTYRTVCSVNGPLVVLDRVKFAQYAEIVHFTLPDGTQ
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
33.99
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ATP6V1B1
Entrez GeneID
525GeneBank Accession#
NM_001692Protein Accession#
NP_001683.2Gene Name
ATP6V1B1
Gene Alias
ATP6B1, MGC32642, RTA1B, VATB, VMA2, VPP3
Gene Description
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
Gene Ontology
HyperlinkGene Summary
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness. [provided by RefSeq
Other Designations
H(+)-transporting two-sector ATPase, 58kD subunit|H+-ATPase beta 1 subunit|V-ATPase B1 subunit|endomembrane proton pump 58 kDa subunit|vacuolar proton pump 3|vacuolar proton pump, subunit 3
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Interactome
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Disease
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