ATP2B1 monoclonal antibody (M01), clone 3E2
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant ATP2B1.
Immunogen
ATP2B1 (NP_001673, 1 a.a. ~ 97 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MGDMANNSVAYSGVKNSLKEANHDGDFGITLAELRALMELRSTDALRKIQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFIPPKKPKT
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (99); Rat (100)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.41 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged ATP2B1 is approximately 0.3ng/ml as a capture antibody.ELISA
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Gene Info — ATP2B1
Entrez GeneID
490GeneBank Accession#
NM_001682Protein Accession#
NP_001673Gene Name
ATP2B1
Gene Alias
PMCA1, PMCA1kb
Gene Description
ATPase, Ca++ transporting, plasma membrane 1
Omim ID
108731Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
plasma membrane calcium ATPase 1|plasma membrane calcium pump|plasma membrane calcium-ATPase
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Interactome
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Pathway
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Disease
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