ATP2A3 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human ATP2A3 partial ORF ( AAH35729, 501 a.a. - 620 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
TRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIR
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
38.94
Interspecies Antigen Sequence
Mouse (90); Rat (88)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ATP2A3
Entrez GeneID
489GeneBank Accession#
BC035729Protein Accession#
AAH35729Gene Name
ATP2A3
Gene Alias
SERCA3
Gene Description
ATPase, Ca++ transporting, ubiquitous
Omim ID
601929Gene Ontology
HyperlinkGene Summary
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
ATPase, Ca(2+)-transporting, ubiquitous|SR Ca(2+)-ATPase 3|adenosine triphosphatase, calcium|calcium pump 3|calcium-translocating P-type ATPase|sarco/endoplasmic reticulum Ca2+ -ATPase|sarco/endoplasmic reticulum Ca2+ ATPase|sarcoplasmic/endoplasmic retic
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Interactome
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Pathway
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Disease
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Publication Reference
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Inhibition and conformational change of SERCA3b induced by Bcl-2.
Hewarathna A, Dremina E, Schöneich C.
Biochimica et Biophysica Acta 2016 Sep; 1865(1):121.
Application：WB, Quan, Human, HEK 293 cells.
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Inhibition and conformational change of SERCA3b induced by Bcl-2.
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