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ELISA

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

ATP2A1

Gene Alias

ATP2A, SERCA1

Gene Description

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

Omim ID

Gene Ontology

Gene Summary

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq

Other Designations

ATPase, Ca++ transporting, fast twitch 1|OTTHUMP00000162562|SR Ca(2+)-ATPase 1|calcium pump 1|calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform|endoplasmic reticulum class 1/2 Ca(2+) ATPase|sarcoplasmic/endoplasm