ATF3 (Human) Recombinant Protein (P01)
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More Files
- More Functions
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Specification
Product Description
Human ATF3 full-length ORF ( AAH06322, 1 a.a. - 181 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSSALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKESEKLESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQS
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
45.65
Interspecies Antigen Sequence
Mouse (95); Rat (95)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ATF3
Entrez GeneID
467GeneBank Accession#
BC006322Protein Accession#
AAH06322Gene Name
ATF3
Gene Alias
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Gene Description
activating transcription factor 3
Omim ID
603148Gene Ontology
HyperlinkGene Summary
Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes. [provided by RefSeq
Other Designations
ATF3deltaZip2|ATF3deltaZip2c|ATF3deltaZip3|OTTHUMP00000034887|OTTHUMP00000034890
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Interactome
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Disease
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Publication Reference
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SUMOylation of ATF3 alters its transcriptional activity on regulation of TP53 gene.
Wang CM, Brennan VC, Gutierrez NM, Wang X, Wang L, Yang WH.
Journal of Cellular Biochemistry 2013 Mar; 114(3):589.
Application:Incubated, Recombinant protein.
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DETERMINANTS OF TETHERIN ANTAGONISM IN THE TRANSMEMBRANE DOMAIN OF THE HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 (HIV-1) VPU PROTEIN.
Vigan R, Neil SJ.
Journal of Virology 2010 Dec; 84(24):12958.
Application:Flow Cyt, Human, HeLa cells.
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Determination of complementary antibody pairs using protein A capture with the AlphaScreen assay format.
Bembenek ME, Burkhardt A, Ma J, Li Z, Loke HK, Wu D, Xu Q, Tayber O, Xie L, Li P, Li L.
Analytical Biochemistry 2011 Jan; 408(2):321.
Application:ELISA, Func, Rabbit, Rabbit blood.
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SUMOylation of ATF3 alters its transcriptional activity on regulation of TP53 gene.
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